Anti-invasive and anti-metastatic effects of novel TGF beta inhibitor analogues

Local invasion and metastasis are the deadliest characteristics of cancer, as they account for the majority of cancer associated deaths. However, the wide range of invasive phenotypes, and the ability of cancer cells to switch among them, has prevailed the development of antimetastatic therapies. Recently, we have established the concept of migrastatics as drugs targeted against common features of invasion modes, stressing the requirement to evaluate drugs based on anti-invasive, rather than anti-proliferative, properties.
The aim of the proposed project would be to investigate novel migrastatic candidates identified based on a large screen of TGF beta inhibitors analogues. The most promising compound shown to inhibit cancer cell invasion in our pilot screen was further modified in order to enhance its migrastatic properties. The ability of the novel compounds to inhibit canc
er cell invasion will be extensively studied by the applicant both in vitro and in vivo, together with the molecular mechanisms underlying their migrastatic properties.
The work of the applicant will concentrate on three main aims: i) to analyze the anti-invasive effects of novel TGF beta inhibitors analogs in vitro, ii) to elucidate the molecular mechanisms, through which the anti-invasive effects of compounds are exerted, iii) to analyze the effect of selected compounds on experimental tumors and metastasizing in vivo.
The proposal will lead to the development of novel anti-invasive and anti-metastatic compounds with considerable potential for the translation into the cli

Funding and project approval: 

  • co-founding 1000 EUR/month is ensured
  • project is approved by head of corresponding department

Co-founding resources:
Research of the Cancer Microenvironment Supporting Cancer Growth and Spread 
Reg. No. CZ.02.1.01/0.0/0.0/16_019/0000785

Required application materials: 

  • Application Form, available from here.
  • Letter of Reference: written even by the supervisor in the PhD programme or by a researcher/head of establishment, where the applicant completed the doctoral study. Available from here.
  • Scientific CV + List of Publications: all together max. 2 pages A4.
  • Copy of University Diploma or Provisional certificate of completion of PhD studies or another official confirmation, that the applicant has been awarded PhD Degree.

How to submit application materials: 
Please send email with the required application materials to Assoc. Prof. Jan Brábek:, Faculty of Science, Charles University, Prague. 

Application deadline:
The application deadline is July 23, 2021.

More information:
For more information please visit the webpage of the JUNIOR Fund project of the Charles University.

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