Project: Development of enantioselective methodologies based on multi-catalytic systems
Research group: Asymmetric synthesis
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Development of new methodologies that allow building interesting scaffolds with the formation of minimum waste and the consumption of minimum resources is a current trend in organic synthesis. To date, a range of multi-catalysis concepts have been developed affording new reactions, some of them unattainable by single catalysis. Multi-catalysis in not a new concept, it is worldwide occurring concept in Nature. Many enzymes operate through the cooperation of two or more catalytic moieties in an active site to afford a specific transformation. With respect to above mentioned the PhD project will be focused on the development of new catalytic asymmetric methods using combination of small organic molecules, such as amines, phosphines, carboxylic, sulfonic and phosphoric acids. The developed methods will be applied to the enantioselective synthesis of naturally occuring compounds as well as molecules with biological activity.
Dočekal, V.; Šimek, M.; Dračínský, M.; Veselý, J. Chem.-Eur. J. 2018, 24, 13441.
Meazza, M.; Kamlar, M.; Jašíková, L.; Formánek, B.; Mazzanti, A.; Roithová, J.; Veselý, J.; Rios, R. Chem. Sci. 2018, 9, 6368.
Gergelitsová, I,; Tauchman, J.; Císařová, I.; Veselý, J. Synlett 2015, 26, 2690-2696.
Czech Science Foundation grants: 17-20645S “Combined organo- and metal- catalysis (CORMECA)”
MSc. or equivalent in chemistry or medicinal chemistry, an experience with organic synthesis, good knowledge of English
Deadline is closed