Project: Regeneration potential of Sertoli cells
Research group: Krylov
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Regeneration is important field of modern medicine, because of a limited regeneration capacity of adult mammals, in contrast to amphibians. A key factor behind regeneration capacity is different immune response to injury. Stem cells has been proposed to replace regeneration deficit in mammals. Unfortunately, clinical outcomes of stem cell transplantation in regenerative medicine remain poor, so there is a continuous demand for cells with better capacity to restore damaged tissues function. In recent years, immune-tolerable stem-like Sertoli cells (SCs) have been introduced as a potential solution. PhD applicant would study a behavior and gene expression of isolated and defined SCs after transplantation to allo- and xenogeneic recipients with or without injury using two evolutionary distant species, Xenopus and Mus musculus or rat, which represent full and partial regenerative systems. Regeneration properties of SCs will be evaluated and changes of gene expression among host and recipient cells will be studied at a single cell level to elucidate molecular mechanism underlying their differentiation and regeneration and immune response.
Deadline is closed