Antigen presentation is the essential mechanism required for activation and regulation of adaptive immune responses to pathogens or commensals. Antigens derived intestinal microbes can be actively acquired directly by antigen presenting cells (APCs) using endocytosis or indirectly by various means of antigen transfer between cells of the immune system. Recently, innate lymphoid cells type 3 (ILC3) were identified as a crucial APCs able on one hand to induce tolerance to harmless commensals and on the other hand promote efficient immune response to mucosal pathogens, such as Candida albicans.
Our preliminary data suggest, that ILC3 cells and myeloid APCs could cooperate in antigen transfer and adaptive immunity fate-decision making. Therefore, this project will focus to determine the cellular and molecular component of myeloid-ILC3 interaction. The project aims to clarify the importance of myeloid-ILC3 cooperation both in physiology (i.e. tolerance to commensals) and in infection. To address these scientific questions, project will combine advanced animal models, single cell transcriptomics, flow cytometry and advanced in vivo microscopy techniques.
The project is well suited for students with deep interest in mucosal immunology, biology of infectious diseases or host-microbe interactions. Our team is deeply interested in host-pathogen interaction, antigen presentation by non-classical antigen presenting cells and regulation of adaptive immune responses. We are looking for talented, friendly and enthusiastic new lab member with proven laboratory experience. Although the strong background in immunology, cell biology and molecular biology is a great advantage, motivation is the most important requirement.Apply to the project